|
KMID : 0359819930220050659
|
|
Journal of Korean Neurosurgical Society
1993 Volume.22 No. 5 p.659 ~ p.665
|
|
|
An Integrated Logistic Formula for Dose Prescription in Radiosurgery
|
|
박용구
정상섭/장진우/조준/김기홍
|
|
|
Abstract
|
|
|
Radiation necrosis is the main obstacle for radiosurgery delivering high dose ionizing radiation inhomogeneoursly into small field of lesion with spatial accuracy. The complication probability is closely related to dose-volume effect. To reduce
the
complication rate, the optimum dose should be prescribed for the isodose curve enclosing the target lesion according to the lesion volume and isodose fall-off. However, the shape, volum and isodose fall-off of the lesions are different from each
other.
To choose the optimum doses for radiosurgery in each case, it is necessary to have a reasonable model for predicting dose-volume effects. Flickinger developed an integrated logistic formula using normalized total dose (NTD) as a reasonable model
to
predict complications from gamma knife radiosurgery. The authors developed a computer program to calculate the risk probability using that formula. As previously emphasized, the risk probability derived from the formula is useful and
indispensable
as a
guidance to dose prescription in gamma knife surgery.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|